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Download eM Client for free and set up your Open-Xchange.com account.
eM Client is able to detect the settings recommended by your email provider using its Automatic account setup, but in some cases, the offered settings might be out of date in which case, a manual setup can come in handy.
In eM Client, go to Menu > Accounts and use the Mail > Other setup option. Then insert your email address and other necessary credentials and server settings provided above.